Title : Disruption of the mouse protein tyrosine kinase 6 gene prevents STAT3 activation and confers resistance to azoxymethane.

Pub. Date : 2011 Oct

PMID : 21741923






2 Functional Relationships(s)
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1 Induction of PTK6 increased apoptosis, proliferation, and STAT3 activation in Ptk6+/+ mice injected with azoxymethane. Azoxymethane signal transducer and activator of transcription 3 Mus musculus
2 CONCLUSIONS: PTK6 promotes STAT3 activation in the colon following injection of the carcinogen azoxymethane and regulates STAT3 activity in mouse colon tumors and in the HCT116 and young adult mouse colon cell lines. Azoxymethane signal transducer and activator of transcription 3 Mus musculus