Pub. Date : 2011 May
PMID : 21739721
3 Functional Relationships(s)Download |
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Sentence | Compound Name | Protein Name | Organism |
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1 | An acetylation-mono-ubiquitination switch on lysine 120 of H2B. | Lysine | H2B clustered histone 21 | Homo sapiens | ||
2 | Lysine 120 of H2B is modified by two PTMs: ubiquitination, which is required for further trans-tail H3 methylations and elongation, and acetylation, whose role is less clear. | Lysine | H2B clustered histone 21 | Homo sapiens | ||
3 | Our data point at acetylation of Lysine 120 of H2B as an early mark of poised or active state and establish a temporal sequence between acetylation and mono-ubiquitination of this H2B residue. | Lysine | H2B clustered histone 21 | Homo sapiens |