Title : Phosphatidic acid activates mammalian target of rapamycin complex 1 (mTORC1) kinase by displacing FK506 binding protein 38 (FKBP38) and exerting an allosteric effect.

Pub. Date : 2011 Aug 26

PMID : 21737445






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Phospholipase D 1, a PA-generating enzyme that is an established upstream regulator of mTORC1, is found to negatively affect mTOR-FKBP38 interaction, confirming the role of endogenous PA in this regulation. Phosphatidic Acids phospholipase D1 Homo sapiens
2 Phospholipase D 1, a PA-generating enzyme that is an established upstream regulator of mTORC1, is found to negatively affect mTOR-FKBP38 interaction, confirming the role of endogenous PA in this regulation. Phosphatidic Acids phospholipase D1 Homo sapiens