Title : Involvement of protein kinase Cdelta/extracellular signal-regulated kinase/poly(ADP-ribose) polymerase-1 (PARP-1) signaling pathway in histamine-induced up-regulation of histamine H1 receptor gene expression in HeLa cells.

Pub. Date : 2011 Sep 2

PMID : 21730054






3 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Histamine or PMA stimulation resulted in PKCdelta phosphorylation at Tyr(311) and Thr(505). Histamine protein kinase C delta Homo sapiens
2 Histamine or PMA caused translocation PKCdelta from the cytosol to the Golgi. Histamine protein kinase C delta Homo sapiens
3 These results suggest the involvement of the PKCdelta/ERK/poly(ADP-ribose) polymerase-1 signaling pathway in histamine- or PMA-induced up-regulation of H1R gene expression in HeLa cells. Histamine protein kinase C delta Homo sapiens