Pub. Date : 2011 Jul 5
PMID : 21726460
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We hypothesized that subcutaneous injections of enoxaparin would decrease the effects of hyperoxia on high-tidal-volume ventilation-induced HMGB1 production and neutrophil infiltration via the serine/threonine kinase/protein kinase B (Akt) pathway. | Enoxaparin | thymoma viral proto-oncogene 1 | Mus musculus |
| 2 | Hyperoxia-induced augmentation of ventilator-induced lung injury was attenuated with Akt deficient mice and pharmacological inhibition of Akt activity by enoxaparin. | Enoxaparin | thymoma viral proto-oncogene 1 | Mus musculus |
| 3 | CONCLUSION: These data suggest that enoxaparin attenuates hyperoxia-augmented high-tidal-volume ventilation-induced neutrophil influx and HMGB1 production through inhibition of the Akt pathway. | Enoxaparin | thymoma viral proto-oncogene 1 | Mus musculus |