Title : Sex and dosing-time dependencies in irinotecan-induced circadian disruption.

Pub. Date : 2011 May

PMID : 21721861






1 Functional Relationships(s)
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1 However, the average expression of Rev-erbalpha, Per2, and Bmal1 were down-regulated 2- to 10-fold with irinotecan at the worst ZT, while being minimally or unaffected at the best ZT, irrespective of sex. Irinotecan period circadian clock 2 Mus musculus