Pub. Date : 2011 Aug
PMID : 21692989
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tyrosine phosphorylation of tau regulates its interactions with Fyn SH2 domains, but not SH3 domains, altering the cellular localization of tau. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 2 | We also show that tau interacts with the SH2 domain of Fyn, and that this association, unlike that of Fyn-SH3, is influenced by Fyn-mediated tyrosine phosphorylation of tau. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |
| 3 | Finally, we show that tyrosine phosphorylation influences the localization of tau to detergent-resistant membrane microdomains in primary cortical neurons, and that this trafficking is Fyn-dependent. | Tyrosine | FYN proto-oncogene, Src family tyrosine kinase | Homo sapiens |