Title : SPARC functions as an anti-stress factor by inactivating p53 through Akt-mediated MDM2 phosphorylation to promote melanoma cell survival.

Pub. Date : 2011 Dec 8

PMID : 21685937






1 Functional Relationships(s)
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1 Finally, we show that overexpression of SPARC renders cells more resistant to the p53-mediated cytotoxic effects of the DNA-damaging drug actinomycin-D. Dactinomycin tumor protein p53 Homo sapiens