Title : Lipid droplets in the secretory response of Leydig cells of normal and hCG-treated rats.

Pub. Date : 1990 Jul

PMID : 2167768






3 Functional Relationships(s)
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1 The following conclusions are drawn: 1) chronic hCG treatment enhances the ability of rat Leydig cells to take-up exogenous cholesterol from circulating lipoproteins, and to store it in lipid droplets as a reserve material; 2) lipid-droplet stored cholesterol is employed only in the case of intense acute stimulation, since, under basal conditions, endogenous cholesterol synthesis is able to meet the requirements for testosterone production alone. Cholesterol hypertrichosis 2 (generalised, congenital) Homo sapiens
2 The following conclusions are drawn: 1) chronic hCG treatment enhances the ability of rat Leydig cells to take-up exogenous cholesterol from circulating lipoproteins, and to store it in lipid droplets as a reserve material; 2) lipid-droplet stored cholesterol is employed only in the case of intense acute stimulation, since, under basal conditions, endogenous cholesterol synthesis is able to meet the requirements for testosterone production alone. Cholesterol hypertrichosis 2 (generalised, congenital) Homo sapiens
3 The following conclusions are drawn: 1) chronic hCG treatment enhances the ability of rat Leydig cells to take-up exogenous cholesterol from circulating lipoproteins, and to store it in lipid droplets as a reserve material; 2) lipid-droplet stored cholesterol is employed only in the case of intense acute stimulation, since, under basal conditions, endogenous cholesterol synthesis is able to meet the requirements for testosterone production alone. Cholesterol hypertrichosis 2 (generalised, congenital) Homo sapiens