Title : Monoubiquitination of H2AX protein regulates DNA damage response signaling.

Pub. Date : 2011 Aug 12

PMID : 21676867






1 Functional Relationships(s)
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1 As a functional consequence, we show that the H2AX K120R mutant abolishes H2AX monoubiquitination, impairs the recruitment of p-ATM (Ser(1981)) to DSBs, and thereby reduces the formation of gamma-H2AX and the recruitment of MDC1 to DNA damage sites. dsbs H2A.X variant histone Homo sapiens