Title : Adeno-associated virus-mediated expression of acid sphingomyelinase decreases atherosclerotic lesion formation in apolipoprotein E(-/-) mice.

Pub. Date : 2011 Jun

PMID : 21674735






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 BACKGROUND: The secretory form of acid sphingomyelinase (ASM) is postulated to play a key role in the retention and aggregation of lipoproteins in the subendothelial space of the arterial wall by converting sphingomyelin in lipoproteins into ceramide. Sphingomyelins sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus
2 RESULTS: Plasma sphingomyelin levels were reduced at early but not later time points after the administration of AAV8-ASM despite persistently elevated circulating ASM. Sphingomyelins sphingomyelin phosphodiesterase 1, acid lysosomal Mus musculus