Title : Disulfide scrambling in IgG2 monoclonal antibodies: insights from molecular dynamics simulations.

Pub. Date : 2011 Dec

PMID : 21671135






1 Functional Relationships(s)
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1 RESULTS: Two Fabs move towards Fc asymmetrically repeatedly leading to spatial proximity of LC.Cys214 and HC.Cys128 residues in one Fab with Cys residues in the upper hinge region, which could initiate disulfide scrambling. Disulfides FA complementation group B Homo sapiens