Title : Phosphodiesterase 4B in the cardiac L-type Ca²⁺ channel complex regulates Ca²⁺ current and protects against ventricular arrhythmias in mice.

Pub. Date : 2011 Jul

PMID : 21670503






2 Functional Relationships(s)
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1 Here we show that both PDE4B and PDE4D are tethered to the LTCC in the mouse heart but that beta-AR stimulation of the L-type Ca2+ current (ICa,L) is increased only in Pde4b-/- mice. isocyanic acid adrenergic receptor, beta 1 Mus musculus
2 These results identify PDE4B in the CaV1.2 complex as a critical regulator of ICa,L during beta-AR stimulation and suggest that distinct PDE4 subtypes are important for normal regulation of Ca2+-induced Ca2+ release in cardiomyocytes. isocyanic acid adrenergic receptor, beta 1 Mus musculus