Title : Novel suppression mechanism operating in early phase of adipogenesis by positive feedback loop for enhancement of cyclooxygenase-2 expression through prostaglandin F2α receptor mediated activation of MEK/ERK-CREB cascade.

Pub. Date : 2011 Aug

PMID : 21668646






2 Functional Relationships(s)
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1 COX-2 expression was enhanced with a peak at 1 h for the mRNA level and at 3 h for the protein level after the addition of Fluprostenol, an FP receptor agonist. fluprostenol cytochrome c oxidase II, mitochondrial Mus musculus
2 The Fluprostenol-derived elevation of COX-2 expression was suppressed by the co-treatment with an FP receptor antagonist, AL8810, with a mitogen-activated protein kinase (MEK; ERK kinase) inhibitor, PD98059. fluprostenol cytochrome c oxidase II, mitochondrial Mus musculus