Title : Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats.

Pub. Date : 2011 Jul

PMID : 21664393






5 Functional Relationships(s)
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1 Adrenomedullin protects against fructose-induced insulin resistance and myocardial hypertrophy in rats. Fructose adrenomedullin Rattus norvegicus
2 Fructose-fed rats showed increased immunoreactive-ADM content in plasma by 110% and in myocardia by 55% and increased mRNA level in myocardia and vessels (all P<0.01). Fructose adrenomedullin Rattus norvegicus
3 Our results showed upregulation of endogenous ADM during fructose-induced IR and the protective effect of ADM on fructose-induced IR and concomitant cardiovascular hypertrophy probably by its antioxidant effect, which suggests that ADM could be an endogenous protective factor in IR. Fructose adrenomedullin Rattus norvegicus
4 Our results showed upregulation of endogenous ADM during fructose-induced IR and the protective effect of ADM on fructose-induced IR and concomitant cardiovascular hypertrophy probably by its antioxidant effect, which suggests that ADM could be an endogenous protective factor in IR. Fructose adrenomedullin Rattus norvegicus
5 Our results showed upregulation of endogenous ADM during fructose-induced IR and the protective effect of ADM on fructose-induced IR and concomitant cardiovascular hypertrophy probably by its antioxidant effect, which suggests that ADM could be an endogenous protective factor in IR. Fructose adrenomedullin Rattus norvegicus