Pub. Date : 2012 Apr
PMID : 21658928
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Alpha-linolenic acid increases cholesterol efflux in macrophage-derived foam cells by decreasing stearoyl CoA desaturase 1 expression: evidence for a farnesoid-X-receptor mechanism of action. | alpha-Linolenic Acid | stearoyl-CoA desaturase | Homo sapiens |
| 2 | This study investigated the mechanisms by which ALA regulated SCD1 and subsequent effect on cholesterol storage and transport in MDFCs. | alpha-Linolenic Acid | stearoyl-CoA desaturase | Homo sapiens |
| 3 | Alpha-linolenic acid treatment and SCD1 siRNA significantly decreased SCD1 expression in MDFCs. | alpha-Linolenic Acid | stearoyl-CoA desaturase | Homo sapiens |
| 4 | Alpha-linolenic acid activated the nuclear receptor farnesoid-X-receptor, which in turn increased its target gene small heterodimer partner (SHP) expression, and decreased liver-X-receptor dependent sterol regulatory element binding protein 1c transcription, ultimately resulting in repressed SCD1 expression. | alpha-Linolenic Acid | stearoyl-CoA desaturase | Homo sapiens |
| 5 | In conclusion, repression of SCD1 by ALA favorably increased cholesterol efflux and decreased cholesterol accumulation in foam cells. | alpha-Linolenic Acid | stearoyl-CoA desaturase | Homo sapiens |