Title : Effect of extracellular Na on isoproterenol-induced cAMP levels in depolarized uterus.

Pub. Date : 1978 Dec 15

PMID : 216559






4 Functional Relationships(s)
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1 Effect of extracellular Na on isoproterenol-induced cAMP levels in depolarized uterus. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
2 While the degree of relaxation by isoproterenol was similar in all three media, isoproterenol (10(-4)M) increased cAMP by 100% in Na+ free depolarizing media, by 337% in Na+ containing depolarizing medium and by 600% in normal non-depolarizing medium. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
3 After pretreatment of the tissue with 10(-5) M D-600, 10(-4) M isoproterenol increased cAMP levels by 600% in all three depolarzing media. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens
4 Na+ appears to be producing its effect on isoproterenol induced increase in cAMP levels indirectly by reducing the increase in intracellular Ca2+ concentration known to occur with depolarization. Isoproterenol cathelicidin antimicrobial peptide Homo sapiens