Title : Electrophysiological evidence for the existence of GABAA receptors in cultured frog melanotrophs.

Pub. Date : 1990 May 28

PMID : 2165430






9 Functional Relationships(s)
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1 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
2 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
3 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
4 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
5 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
6 The neurotransmitter GABA exerts a biphasic effect on alpha-melanocyte-stimulating hormone (alpha-MSH) secretion from pars intermedia cells: GABA induces a rapid and transient stimulation followed by a sustained inhibition of alpha-MSH release. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
7 Taken together, our results indicate that the rapid and transient stimulation of alpha-MSH release induced by GABA can be accounted for by activation of a chloride conductance which causes membrane depolarization. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
8 These data support the notion that the transient stimulation of alpha-MSH secretion induced by GABA can be accounted for by membrane depolarization which provokes activation of voltage-operated calcium channels. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens
9 Since no evidence was found for GABA-induced hyperpolarization, the intracellular mechanisms leading to the strong inhibitory effect of GABA on alpha-MSH secretion remain to be elucidated. gamma-Aminobutyric Acid proopiomelanocortin Homo sapiens