Pub. Date : 2011 Sep 25
PMID : 21640771
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | After administration, FK506 and CsA mainly distribute within erythrocytes owing to the presence into these cells of immunophilins that bind the drugs with very high affinity (FKBP12 for FK506 and cyclophilin A for CsA); therefore, a new strategy aimed to increase the amount of FK506/CsA carried by erythrocytes by increasing the intra-erythrocytic concentration of the respective binding proteins has been developed. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 2 | Homo sapiens |
| 2 | After administration, FK506 and CsA mainly distribute within erythrocytes owing to the presence into these cells of immunophilins that bind the drugs with very high affinity (FKBP12 for FK506 and cyclophilin A for CsA); therefore, a new strategy aimed to increase the amount of FK506/CsA carried by erythrocytes by increasing the intra-erythrocytic concentration of the respective binding proteins has been developed. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 2 | Homo sapiens |
| 3 | After administration, FK506 and CsA mainly distribute within erythrocytes owing to the presence into these cells of immunophilins that bind the drugs with very high affinity (FKBP12 for FK506 and cyclophilin A for CsA); therefore, a new strategy aimed to increase the amount of FK506/CsA carried by erythrocytes by increasing the intra-erythrocytic concentration of the respective binding proteins has been developed. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 2 | Homo sapiens |
| 4 | Moreover, FK506 released from FKBP12-RBC is able to be up-taken by T lymphocytes and inhibit IL-2 expression in vitro as free administered drug. | Tacrolimus | FKBP prolyl isomerase 1A pseudogene 2 | Homo sapiens |