Pub. Date : 2011 Sep
PMID : 21637924
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tetramethylpyrazine inhibits migration of SKOV3 human ovarian carcinoma cells and decreases the expression of interleukin-8 via the ERK1/2, p38 and AP-1 signaling pathways. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 2 | The role of TMP in association with IL-8 in the tumor cell migratory process remains unclear. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 3 | The purpose of the present study was to determine whether TMP influences the migratory ability of a human ovarian carcinoma cell line (SKOV3) via regulation of IL-8 expression in vitro. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 4 | Cell counts showed that treatment of SKOV3 with TMP (25-100 microg/ml) for 24 h did not decrease cell numbers, while an effect of TMP on the down-regulation of the expression of IL-8 was observed. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 5 | In addition, migration of SKOV3 cells was suppressed after treatment with TMP (25-100 microg/ml) for 24 h. Therefore, expression of IL-8 by SKOV3 cells correlates with their metastatic potential. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |
| 6 | Our data suggest that TMP may inhibit tumor cell invasion and migration, at least in part, through its down-regulation of IL-8 expression. | tetramethylpyrazine | C-X-C motif chemokine ligand 8 | Homo sapiens |