Title : Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling.

Pub. Date : 2011 Sep 2

PMID : 21633967






2 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Canonical notch pathway protects hepatocytes from ischemia/reperfusion injury in mice by repressing reactive oxygen species production through JAK2/STAT3 signaling. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus
2 CONCLUSION: Notch signal protects hepatocytes from I/R injury by Hes5-dependent activation of STAT3, which activates the expression of MnSOD, leading to the scavenging of ROS. Reactive Oxygen Species signal transducer and activator of transcription 3 Mus musculus