Title : Enhanced cell cycle perturbation and apoptosis mediate the synergistic effects of ST1926 and ATRA in neuroblastoma preclinical models.

Pub. Date : 2012 Aug

PMID : 21633925






2 Functional Relationships(s)
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1 In the present study, we show that retinoic acid enhances the cytostatic and apoptogenic properties of the novel adamantyl retinoid ST1926 in a panel of neuroblastoma cells with different p53 status and caspase 8 expression, resulting in synergistic effects as assessed by Combination Index and Isobologram analysis. Tretinoin tumor protein p53 Homo sapiens
2 Although not modulated, p53 appeared to enhance cells responsiveness to retinoid/ATRA combination. Tretinoin tumor protein p53 Homo sapiens