Title : Clofarabine 5'-di and -triphosphates inhibit human ribonucleotide reductase by altering the quaternary structure of its large subunit.

Pub. Date : 2011 Jun 14

PMID : 21628579






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 alpha binds NDP substrates (CDP, UDP, ADP, and GDP, C site) as well as ATP and dNTPs (dATP, dGTP, TTP) allosteric effectors that control enzyme activity (A site) and substrate specificity (S site). deoxyguanosine triphosphate cut like homeobox 1 Homo sapiens