Title : The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma.

Pub. Date : 2011 Jul 28

PMID : 21628402






1 Functional Relationships(s)
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1 Consequently, several lymphoma-related ERK substrates were down-regulated by AZD6244 including MCT-1, c-Myc, Bcl-2, Mcl-1, and CDK1/2. AZD 6244 MYC proto-oncogene, bHLH transcription factor Homo sapiens