Title : Insulin-receptor tyrosine kinase and glucose transport.

Pub. Date : 1990 Jun

PMID : 2162754






3 Functional Relationships(s)
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1 A search for cellular substrates of the receptor kinase revealed that insulin causes accumulation of a 15,000-Mr phosphorylated (on tyrosine) cytosolic protein (pp15) in 3T3-L1 adipocytes treated with oxophenylarsine (PAO). oxophenylarsine nuclear transport factor 2 Mus musculus
2 A search for cellular substrates of the receptor kinase revealed that insulin causes accumulation of a 15,000-Mr phosphorylated (on tyrosine) cytosolic protein (pp15) in 3T3-L1 adipocytes treated with oxophenylarsine (PAO). oxophenylarsine nuclear transport factor 2 Mus musculus
3 PAO blocks turnover of the phosphoryl group of pp15, causing its accumulation, and thereby appears to interrupt signal transmission from the receptor to the glucose-transport system. oxophenylarsine nuclear transport factor 2 Mus musculus