Title : Proteomics identification of ITGB3 as a key regulator in reactive oxygen species-induced migration and invasion of colorectal cancer cells.

Pub. Date : 2011 Oct

PMID : 21622897






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Functional studies showed that ROS markedly up-regulated expression of ITGB3, which in turn promoted an aggressive phenotype in SW480 cells, with concomitant up-regulated expression of STMN1. Reactive Oxygen Species stathmin 1 Homo sapiens
2 Furthermore, STMN1 expression and the PI3K-Akt-mTOR pathway were found to be involved in ROS-induced and ITGB3-mediated migration and invasion of colorectal cancer cells. Reactive Oxygen Species stathmin 1 Homo sapiens