Pub. Date : 2010
PMID : 21614210
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Antiproliferative effects of cucurbitacin B in breast cancer cells: down-regulation of the c-Myc/hTERT/telomerase pathway and obstruction of the cell cycle. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 2 | The expression of hTERT and c-Myc were also inhibited by cucurbitacin B, In addition, a clear reduction of c-Myc protein was observed after treatment in SKBR-3 cells even with a concentration of cucurbitacin B that was ten-times lower compared to the concentration used for HBL-100. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 3 | The expression of hTERT and c-Myc were also inhibited by cucurbitacin B, In addition, a clear reduction of c-Myc protein was observed after treatment in SKBR-3 cells even with a concentration of cucurbitacin B that was ten-times lower compared to the concentration used for HBL-100. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 4 | The expression of hTERT and c-Myc were also inhibited by cucurbitacin B, In addition, a clear reduction of c-Myc protein was observed after treatment in SKBR-3 cells even with a concentration of cucurbitacin B that was ten-times lower compared to the concentration used for HBL-100. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 5 | The expression of hTERT and c-Myc were also inhibited by cucurbitacin B, In addition, a clear reduction of c-Myc protein was observed after treatment in SKBR-3 cells even with a concentration of cucurbitacin B that was ten-times lower compared to the concentration used for HBL-100. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
| 6 | Our findings imply that cucurbitacin B exerts an anticancer effect by inhibiting telomerase via down regulating both the hTERT and c-Myc expression in breast cancer cells. | cucurbitacin B | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |