Title : Caspase activity is not required for the mitotic checkpoint or mitotic slippage in human cells.

Pub. Date : 2011 Jul 15

PMID : 21613548






1 Functional Relationships(s)
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1 When satisfaction of the MC was prevented with 500 nM nocodazole or 2.5 muM dimethylenastron (an Eg5 inhibitor), 92-100% of RPE-1 cells slipped from mitosis in the presence of pan-caspase inhibitors or after simultaneously depleting caspase-3 and -9, and they did so with the same kinetics (~21-22 h) as after treatment with nocodazole or Eg5 inhibitors alone. Nocodazole caspase 3 Homo sapiens