Title : Synaptotagmin 1 modulates lipid acyl chain order in lipid bilayers by demixing phosphatidylserine.

Pub. Date : 2011 Jul 15

PMID : 21610074






2 Functional Relationships(s)
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1 Independent evidence for lipid demixing is obtained from fluorescence self-quenching of labeled lipid and from natural abundance (13)C NMR, where heteronuclear single quantum correlation spectra reveal Ca(2+)-dependent chemical shift changes for PS, but not for phosphatidylcholine, in the presence of the syt1 C2 domains. Phosphatidylserines synaptotagmin 1 Homo sapiens
2 The ability of syt1 to demix PS is observed in a range of lipid mixtures that includes cholesterol, phosphatidylethanolamine, and varied PS content. Phosphatidylserines synaptotagmin 1 Homo sapiens