Pub. Date : 2011 Jul 15
PMID : 21606497
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Tristetraprolin mediates anti-inflammatory effects of nicotine in lipopolysaccharide-stimulated macrophages. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 2 | Here we show that in LPS-stimulated human macrophages the anti-inflammatory action of nicotine is mediated by TTP. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 3 | Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 4 | Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 5 | Nicotine induced activation of STAT3 enhanced STAT3 binding to the TTP promoter, increased TTP promoter activity, and increased TTP expression resulting in the suppression of LPS-stimulated TNF-alpha production. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 6 | Overexpression of a dominant negative mutant of STAT3 (R382W) or down-regulation of STAT3 by siRNA abolished nicotine-induced TTP expression and suppression of LPS-stimulated TNF-alpha production. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 7 | However, siRNA to TTP abrogated these effects of nicotine. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 8 | In this experiment, we are reporting for the first time the involvement of TTP in the cholinergic anti-inflammatory cascade consisting of nicotine-STAT3-TTP-dampening inflammation. | Nicotine | ZFP36 ring finger protein | Homo sapiens |
| 9 | In this experiment, we are reporting for the first time the involvement of TTP in the cholinergic anti-inflammatory cascade consisting of nicotine-STAT3-TTP-dampening inflammation. | Nicotine | ZFP36 ring finger protein | Homo sapiens |