Title : Soy isoflavones sensitize cancer cells to radiotherapy.

Pub. Date : 2011 Jul 15

PMID : 21605661






2 Functional Relationships(s)
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1 Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-kappaB, and HIF-1alpha, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Isoflavones apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens
2 Soy isoflavones could be an effective complementary treatment given that they inhibit the survival signaling pathways of various cancer cells through altered activation of APE1/Ref-1, NF-kappaB, and HIF-1alpha, which are genes essential for tumor cell survival, tumor growth, and angiogenesis, thus making such cells more sensitive to radiotherapy. Isoflavones apurinic/apyrimidinic endodeoxyribonuclease 1 Homo sapiens