Title : Influence of polymorphisms in MTHFR 677 C→T, TYMS 3R→2R and MTR 2756 A→G on NSCLC risk and response to platinum-based chemotherapy in advanced NSCLC.

Pub. Date : 2011 Jun

PMID : 21605004






2 Functional Relationships(s)
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1 In addition, we found that patients with the MTHFR 677 TT genotype showed a better response to platinum-based chemotherapy in the recessive model (TT vs CT + CC adjusted OR: 0.24; 95% CI: 0.09-0.68; p = 0.007), the generalized OR was 0.44 (0.22-0.88; p = 0.04). Platinum methylenetetrahydrofolate reductase Homo sapiens
2 Our results suggest that genetic polymorphisms of MTHFR 677 C T may contribute to NSCLC development in Chinese women and could also influence treatment response for advanced NSCLC patients with platinum-based chemotherapy. Platinum methylenetetrahydrofolate reductase Homo sapiens