Title : Inhibitory effect of genistein on a tumor promoter-induced c-fos and c-jun expression in mouse skin.

Pub. Date : 1996 Jan

PMID : 21594328






4 Functional Relationships(s)
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1 The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
2 The effects of genistein, a soybean isoflavone, on 12-O-tetradecanoyl phorbol-13-acetate (TPA)-induced expression of c-fos and c-jun in CD-1 mouse skin have been investigated. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
3 A promoting dose (8.5 mu mol) of TPA significantly increases transcript levels of c-fos, and 2.7 and 3.2 kb c-jun mRNA in mouse skin by 7.0-, 3.2-, and 1.7-fold, respectively. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus
4 Genistein exhibited only a weak suppressive effect on TPA-induced c-jun mRNA expression. Tetradecanoylphorbol Acetate jun proto-oncogene Mus musculus