Title : STAT3 plays a critical role in KRAS-induced pancreatic tumorigenesis.

Pub. Date : 2011 Jul 15

PMID : 21586612






1 Functional Relationships(s)
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1 Large-scale screening of cancer cell lines with a JAK2 inhibitor that blocks STAT3 function revealed a more than 30-fold range in sensitivity in PDAC, and showed a close correlation of sensitivity with levels of tyrosine-phosphorylated STAT3 and of the gp130 receptor, an upstream signaling component. pdac signal transducer and activator of transcription 3 Mus musculus