Title : α-Tocopherol impairs 7-ketocholesterol-induced caspase-3-dependent apoptosis involving GSK-3 activation and Mcl-1 degradation on 158N murine oligodendrocytes.

Pub. Date : 2011 Sep

PMID : 21575614






2 Functional Relationships(s)
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1 With alpha-tocopherol (400 muM), which was capable of counteracting 7-ketocholesterol-induced apoptosis, Akt and GSK3beta dephosphorylation were inhibited as well as Mcl-1 degradation. 7-ketocholesterol thymoma viral proto-oncogene 1 Mus musculus
2 These data underline that the potential protective effects of alpha-tocopherol against 7-ketocholesterol-induced apoptosis do not depend on the cell line considered, and that the cascade of events (Akt/GSK3beta/Mcl-1) constitutes a link between 7-ketocholesterol-induced cytoplasmic membrane dysfunctions and mitochondrial depolarisation leading to apoptosis. 7-ketocholesterol thymoma viral proto-oncogene 1 Mus musculus