Title : Impact of abcc2 [multidrug resistance-associated protein (MRP) 2], abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate.

Pub. Date : 2011 Aug

PMID : 21566011






3 Functional Relationships(s)
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1 We have shown before that ABCC2, ABCC3, and ABCG2 together influence the pharmacokinetics of the anticancer and antirheumatic drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) after intravenous MTX administration. 7-hydroxymethotrexate ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus
2 We have shown before that ABCC2, ABCC3, and ABCG2 together influence the pharmacokinetics of the anticancer and antirheumatic drug methotrexate (MTX) and its toxic metabolite 7-hydroxymethotrexate (7OH-MTX) after intravenous MTX administration. 7-hydroxymethotrexate ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus
3 The absence of Abcc2 and/or Abcg2 also led to significantly increased liver and kidney levels of 7OH-MTX. 7-hydroxymethotrexate ATP-binding cassette, sub-family C (CFTR/MRP), member 2 Mus musculus