Title : Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts.

Pub. Date : 2011 Aug

PMID : 21562093






4 Functional Relationships(s)
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1 Cross talk between cAMP and p38 MAPK pathways in the induction of leptin by hCG in human placental syncytiotrophoblasts. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
2 Activation of the cAMP pathway with dibutyryl cAMP (db cAMP) or forskolin recapitulated the stimulatory effect of hCG on leptin expression. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
3 Activation of the cAMP pathway with dibutyryl cAMP (db cAMP) or forskolin recapitulated the stimulatory effect of hCG on leptin expression. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens
4 These data suggest that endogenous hCG plays a significant role in maintaining leptin production in human placental syncytiotrophoblasts, and this effect involves a cross talk between cAMP and p38 MAPK pathways. Cyclic AMP hypertrichosis 2 (generalised, congenital) Homo sapiens