Title : Lipoxygenases mediate the effect of essential fatty acid in skin barrier formation: a proposed role in releasing omega-hydroxyceramide for construction of the corneocyte lipid envelope.

Pub. Date : 2011 Jul 8

PMID : 21558561






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 12R-LOX forms 9R-hydroperoxy-linoleoyl-omega-hydroxyceramide, further converted by eLOX3 to specific epoxyalcohol (9R,10R-trans-epoxy-11E-13R-hydroxy) and 9-keto-10E,12Z esters of the ceramide; an epoxy-ketone derivative (9R,10R-trans-epoxy-11E-13-keto) is the most prominent oxidized ceramide in mouse skin. -trans-epoxy-11e-13-keto arachidonate 12-lipoxygenase, 12R type Mus musculus