Title : Inhibition of acid ceramidase by a 2-substituted aminoethanol amide synergistically sensitizes prostate cancer cells to N-(4-hydroxyphenyl) retinamide.

Pub. Date : 2011 Jul

PMID : 21557271






1 Functional Relationships(s)
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1 CONCLUSION: This study shows that 4-HPR cytotoxicity is enhanced in a synergistic fashion by inclusion of the AC inhibitor DM102, by a mechanism that enlists generation of ROS, and thus provides a system to raise 4-HPR therapeutic potential. Reactive Oxygen Species N-acylsphingosine amidohydrolase 1 Homo sapiens