Pub. Date : 2011
PMID : 21552197
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dopamine selectively modulates lipopolysaccharide-induced TNF-alpha, IFN-gamma and IL-10 within mice tissues. | Dopamine | interferon gamma | Mus musculus |
| 2 | Furthermore, systemic administration of DA (0.5-50 mg/kg) in mice suppressed significantly LPS-induced TNF-alpha levels in blood, liver, spleen, brain, and lungs; IL-10 levels in blood, brain and liver; and IFN-gamma levels in blood, liver, brain, and lungs. | Dopamine | interferon gamma | Mus musculus |
| 3 | Administration of Clozapine (54 mg/kg) or Haloperidol (62 mg/kg) with LPS (1 microg) and DA (5 mg/kg) reversed DA suppressive effects on LPS-induced cytokines in blood, IFN-gamma in brain and lungs, and enhanced significantly LPS-induced IL-10 production in blood, spleen, liver, and lungs. | Dopamine | interferon gamma | Mus musculus |