Pub. Date : 2011 Jul
PMID : 21550660
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Notably, when 5-AzadC was combined with HDACI MS-275, apoptosis in MV4-11 TP53 R248W cells was significantly enhanced in parallel with activation of the caspase cascade, up-regulation of p21waf1 and gamma-H2AX, and down-regulation of Mcl-1. | Decitabine | tumor protein p53 | Homo sapiens |
2 | Interestingly, inhibition of caspase 3 by the pan-caspase inhibitor attenuated the combination of 5-AzadC and MS-275-mediated apoptosis and down-regulation of Mcl-1 in MV4-11 TP53 R248W cells. | Decitabine | tumor protein p53 | Homo sapiens |
3 | Combination of 5-AzadC and MS-275 may be a promising treatment strategy for individuals with leukemia in which TP53 is inactivated. | Decitabine | tumor protein p53 | Homo sapiens |