Title : Simultaneous inhibition of DNA methyltransferase and histone deacetylase induces p53-independent apoptosis via down-regulation of Mcl-1 in acute myelogenous leukemia cells.

Pub. Date : 2011 Jul

PMID : 21550660






3 Functional Relationships(s)
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1 Notably, when 5-AzadC was combined with HDACI MS-275, apoptosis in MV4-11 TP53 R248W cells was significantly enhanced in parallel with activation of the caspase cascade, up-regulation of p21waf1 and gamma-H2AX, and down-regulation of Mcl-1. Decitabine tumor protein p53 Homo sapiens
2 Interestingly, inhibition of caspase 3 by the pan-caspase inhibitor attenuated the combination of 5-AzadC and MS-275-mediated apoptosis and down-regulation of Mcl-1 in MV4-11 TP53 R248W cells. Decitabine tumor protein p53 Homo sapiens
3 Combination of 5-AzadC and MS-275 may be a promising treatment strategy for individuals with leukemia in which TP53 is inactivated. Decitabine tumor protein p53 Homo sapiens