Title : Sildenafil ameliorates cognitive deficits and tau pathology in a senescence-accelerated mouse model.

Pub. Date : 2012 Mar

PMID : 21546125






1 Functional Relationships(s)
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1 Interestingly, sildenafil also phosphorylated Akt, which was associated with an increase of glycogen synthase kinase-3beta phosphorylation, providing a plausible explanation for the reductions in tau hyperphosphorylation (AT8 and PHF-1 epitopes) and attenuation of cognitive deficits shown by 9-month-old SAMP8 mice. Sildenafil Citrate thymoma viral proto-oncogene 1 Mus musculus