Pub. Date : 2011 Jul
PMID : 21539534
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Disabled-2 modulates homotypic and heterotypic platelet interactions by binding to sulfatides. | Sulfoglycosphingolipids | DAB adaptor protein 2 | Homo sapiens |
| 2 | Our data show that the surface levels of P-selectin, a platelet transmembrane protein known to bind sulfatides and promote cell-cell interactions, are reduced by Dab2 N-PTB, an event that is reversed in the presence of a mutant form of the protein that is deficient in sulfatide but not in integrin binding. | Sulfoglycosphingolipids | DAB adaptor protein 2 | Homo sapiens |
| 3 | Our data show that the surface levels of P-selectin, a platelet transmembrane protein known to bind sulfatides and promote cell-cell interactions, are reduced by Dab2 N-PTB, an event that is reversed in the presence of a mutant form of the protein that is deficient in sulfatide but not in integrin binding. | Sulfoglycosphingolipids | DAB adaptor protein 2 | Homo sapiens |
| 4 | Importantly, Dab2 N-PTB, but not its sulfatide binding-deficient form, was able to prevent sulfatide-induced platelet aggregation when tested under haemodynamic conditions in microfluidic devices at flow rates with shear stress levels corresponding to those found in vein microcirculation. | Sulfoglycosphingolipids | DAB adaptor protein 2 | Homo sapiens |