Pub. Date : 2012 Jan
PMID : 21538419
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inhibition of Stat3 activation by sanguinarine suppresses prostate cancer cell growth and invasion. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 2 | RESULTS: In this study, we identified sanguinarine as a potent inhibitor of Stat3 activation which was able to suppress prostate cancer growth, migration, and invasion. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 3 | Sanguinarine inhibits constitutive as well as IL6-induced phosphorylation of Stat3 at both Tyr705 and Ser727 in prostate cancer cells. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 4 | The inhibition of Stat3 phosphorylation by sanguinarine correlates with reduction of Janus-activated Kinase 2 (Jak2) and Src phosphorylation. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 5 | Sanguinarine downregulates the expression of Stat3-mediated genes such as c-myc and survivin and inhibits the Stat3 responsive element luciferase reporter activity. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 6 | Sanguinarine downregulates the expression of Stat3-mediated genes such as c-myc and survivin and inhibits the Stat3 responsive element luciferase reporter activity. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 7 | Sanguinarine inhibits the anchorage-independent growth of DU145 and LN-S17 cells expressing constitutively activated Stat3. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 8 | CONCLUSIONS: These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |
| 9 | CONCLUSIONS: These data demonstrate that sanguinarine is a potent Stat3 inhibitor and it could be developed as a therapeutic agent for prostate cancer with constitutive activation of Stat3. | sanguinarine | signal transducer and activator of transcription 3 | Homo sapiens |