Title : Adenosine reduces cell surface expression of toll-like receptor 4 and inflammation in response to lipopolysaccharide and matrix products.

Pub. Date : 2011 Dec

PMID : 21538184






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 TLR4 is activated by lipopolysaccharide (LPS) but also by products of matrix degradation such as hyaluronic acid and heparan sulfate. Hyaluronic Acid toll like receptor 4 Homo sapiens
2 Tumor necrosis factor-alpha production induced by the TLR4 ligands LPS, hyaluronic acid, and heparan sulfate was potently inhibited by Ado (-75% for LPS, P < 0.005). Hyaluronic Acid toll like receptor 4 Homo sapiens