Title : Caffeic Acid Phenethyl Ester (CAPE) derived from propolis, a honeybee product, inhibits growth of breast cancer stem cells.

Pub. Date : 2012 Aug

PMID : 21537887






2 Functional Relationships(s)
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1 Treatment of bCSC with CAPE (4.5-days) decreased CD44 levels by 95%, while another cell population containing 10-100-fold lower CD44 content concurrently increased. caffeic acid phenethyl ester CD44 molecule (Indian blood group) Homo sapiens
2 Results suggest that CAPE causes pronounced changes in bCSC characteristics manifested by inhibition of self renewal, progenitor formation, clonal growth in soft agar, and concurrent significant decrease in CD44 content, all signs of decreased malignancy potential. caffeic acid phenethyl ester CD44 molecule (Indian blood group) Homo sapiens