Title : Tanespimycin and bortezomib combination treatment in patients with relapsed or relapsed and refractory multiple myeloma: results of a phase 1/2 study.

Pub. Date : 2011 Jun

PMID : 21534941






1 Functional Relationships(s)
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1 Pharmacodynamic analyses indicated that tanespimycin plus bortezomib effectively inhibited the proteasome, as evidenced by decreased 20S proteasome activity, and inhibited HSP90, as reflected by increased HSP70 expression. Bortezomib heat shock protein 90 alpha family class A member 1 Homo sapiens