Pub. Date : 2011 Apr 15
PMID : 21525977
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Comparison to the cholesterol free and bound structures of NPC1(NTD) reveals that NPC1L1(NTD) is in a closed conformation and the sterol binding pocket is occluded from solvent. | Sterols | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 2 | CONCLUSION: The structure of NPC1L1(NTD) reveals a degree of flexibility surrounding the entrance to the sterol binding pocket, suggesting a gating mechanism that relies on multiple movements around the entrance to the sterol binding pocket. | Sterols | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |
| 3 | CONCLUSION: The structure of NPC1L1(NTD) reveals a degree of flexibility surrounding the entrance to the sterol binding pocket, suggesting a gating mechanism that relies on multiple movements around the entrance to the sterol binding pocket. | Sterols | NPC1 like intracellular cholesterol transporter 1 | Homo sapiens |