Title : 2,6-Disubstituted pyrazines and related analogs as NR2B site antagonists of the NMDA receptor with anti-depressant activity.

Pub. Date : 2011 Jun 1

PMID : 21524576






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Initial identification of hits in this series focused on a basic, secondary amine side chain which led to good potency, but also presented a hERG liability. Amines ETS transcription factor ERG Homo sapiens