Pub. Date : 2011 Jun
PMID : 21518729
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ATM and p53 regulate FOXM1 expression via E2F in breast cancer epirubicin treatment and resistance. | Epirubicin | tumor protein p53 | Homo sapiens |
| 2 | We also established that there is a loss of p53 function in MCF-7-EPI(R) cells and that epirubicin represses FOXM1 expression at transcription and gene promoter levels through activation of p53 and repression of E2F activity in MCF-7 cells. | Epirubicin | tumor protein p53 | Homo sapiens |
| 3 | Moreover, transient promoter transfection assays showed that epirubicin and its cellular effectors p53 and E2F1 modulate FOXM1 transcription through an E2F-binding site located within the proximal promoter region. | Epirubicin | tumor protein p53 | Homo sapiens |
| 4 | In summary, our data show that ATM and p53 coordinately regulate FOXM1 via E2F to modulate epirubicin response and resistance in breast cancer. | Epirubicin | tumor protein p53 | Homo sapiens |